Dementia threat components comparable for women and men, however not hypertension

Dementia threat components comparable for women and men, however not hypertension

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In a examine of simply over half 1,000,000 folks, George Institute researchers discovered that whereas the hyperlink between a number of mid-life cardiovascular threat components and dementia was comparable for each sexes, for blood strain it was not.

The examine confirmed that each low and hypertension have been related to a larger threat of dementia in males, however for ladies the chance of dementia elevated as blood strain went up.

Lead creator Jessica Gong stated that whereas extra analysis was wanted to confirm these findings, they might level to raised methods of managing threat.

“Our outcomes recommend a extra tailor-made method to treating hypertension could possibly be more practical at stopping future instances of dementia,” she stated.

Dementia is quick changing into a worldwide epidemic, at present affecting an estimated 50 million folks worldwide. That is projected to triple by 2050—primarily pushed by growing old populations. Charges of dementia and related deaths are each recognized to be greater in girls than males.

In 2016 it overtook coronary heart illness because the main reason behind demise in Australian girls and it’s the second main reason behind demise for all Australians.

Within the absence of serious remedy breakthroughs, the main focus has been on decreasing the chance of creating the illness and cardiovascular threat components are more and more recognised as contributors to various kinds of dementia.

To look at intercourse variations in main cardiovascular threat components for dementia, George Institute researchers used the UK Biobank, a large-scale biomedical database that recruited 502,489 Britons aged 40-69 years (free from dementia at examine initiation) between 2006 and 2010.

They discovered that present smoking standing, diabetes, excessive ranges of physique fats, having had a previous stroke, and low socio-economic standing have been all related to a larger threat of dementia to an identical diploma in ladies and men.

However when it got here to blood strain, the connection with dementia threat between the sexes was completely different. Though the explanation for this wasn’t clear, the authors proposed some potential explanations.

“Organic variations between ladies and men might account for the intercourse variations we noticed within the relationship between blood strain and the chance of dementia,” stated Ms Gong.

“However there might also be variations in medical remedy for hypertension. For instance, girls are much less more likely to take treatment as prescribed by their healthcare supplier than males and could also be taking extra drugs and experiencing extra negative effects.”

Whereas there aren’t any efficient therapies for dementia, attempting to scale back the burden of the illness by encouraging more healthy life is the precedence, and the strongest proof factors to blood strain administration.

“Our examine suggests {that a} extra individualised method to treating blood strain in males in comparison with girls might lead to even larger safety towards the event of dementia,” stated Professor Mark Woodward, examine co-author.

“It additionally exhibits the significance of guaranteeing adequate numbers of ladies and men are recruited into research and that the info for ladies and men needs to be analysed individually,” he added.

New clues into why folks with sort 2 diabetes develop dementia

Extra data:
BMC Medication, DOI: 10.1186/s12916-021-01980-z

Offered by
George Institute for World Well being

Dementia threat components comparable for women and men, however not hypertension (2021, Might 18)
retrieved 19 Might 2021

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