Prevalence of COVID-19 amongst hospitalized infants varies with ranges of group transmission

Prevalence of COVID-19 amongst hospitalized infants varies with ranges of group transmission

Transmission electron microscope picture of SARS-CoV-2, the virus that causes COVID-19, rising from human cells. Credit score: NIAID

How frequent COVID-19 is amongst infants could rely on the diploma of the pandemic virus circulating in a group, a brand new examine finds.

Printed on-line June 30 within the journal Pediatrics, the examine discovered particularly that charges of the an infection with the virus that causes COVID-19 had been greater amongst infants hospitalized, not for COVID-19—however as an alternative as a result of they had been being evaluated for a possible critical bacterial an infection (SBI) – during times of excessive COVID-19 circulation in New York Metropolis. The examine additionally discovered charges of COVID-19 positivity on this age group had been decrease when an infection charges within the metropolis had been low.

Led by researchers from NYU Langone Well being, the examine additionally examined the scientific course of the an infection in younger infants and located that the most typical presentation of COVID-19 was a fever with out different signs.

“Enhancing our data of how COVID-19 an infection impacts younger infants is essential for informing scientific observe, and for planning public well being measures corresponding to vaccination distribution,” says Vanessa N. Raabe, MD, assistant professor in NYU Langone’s Departments of Medication and Pediatrics, within the Division of Pediatric Infectious Illnesses, and one of many examine’s principal investigators.

New York Metropolis was the early epicenter of COVID-19 in the US, with greater than 190,000 reported infections through the peak of the NYC epidemic between March and Could in 2020. Three p.c of the reported circumstances had been in kids beneath 18 years of age, though these numbers could underestimate the true incidence given the shortage of satisfactory testing. Most youngsters contaminated with the illness had been asymptomatic or had delicate signs. Nonetheless, circumstances of extreme sickness have been reported and a few experiences counsel younger infants could also be at greater danger for extreme illness than older kids.

Younger infants are sometimes handled with antibiotics within the hospital after they run a fever till docs can be certain they do not have a critical bacterial an infection, corresponding to meningitis or a bloodstream an infection, say the examine authors.

“As a result of fever is a typical symptom of COVID-19 in kids, clinicians should take into account COVID-19 as a possible reason for fever and never solely depend on laboratory or imaging outcomes to information decision-making on whether or not or to not check hospitalized infants for COVID-19,” says Dr. Raabe.

The present examine analyzed information from infants lower than 90 days of age admitted for SBI analysis at NYU Langone Well being hospitals and NYC Well being + Hospitals/Bellevue Hospital between March and December 2020. Amongst 148 infants, 15 p.c examined optimistic for COVID-19, and two of the 22 infants with COVID-19 required ICU admission, however had been discharged safely. Particularly, the group discovered that solely 3 p.c of infants examined optimistic during times of low group circulation, in comparison with 31 p.c in communities with excessive an infection charges.

The group additionally discovered a comparatively low incidence (six p.c) of an infection of the hospitalized infants with different generally occurring viruses, whether or not or not that they had COVID-19. “This seemingly displays community-wide decreases in different respiratory viruses reported in New York through the examine interval resulting from enhanced an infection management practices, like social distancing and masks carrying, on the top of the pandemic,” says Raabe.

The researchers advocate clinicians proceed to evaluate younger infants that current with fevers for bacterial infections, whatever the COVID-19 standing, and given the potential extreme penalties if not handled.

“It might be intuitive that what is occurring in kids displays situations within the surrounding group, however we discover it reassuring that the proof confirms this relationship,” says lead writer Michal Paret, MD, a fellow within the Division of Pediatrics, Division of Pediatric Infectious Illnesses at NYU Langone. “The epidemiology of COVID-19 continues to evolve with the emergence of variant viruses and vaccination implementation. Within the face of those adjustments physicians must proceed learning this age group, with the aim of figuring out finally whether or not a selective or common testing technique greatest serves the well being of infants long-term.”


Younger infants produce robust immune response to SARS-CoV-2, examine finds


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NYU Langone Well being


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Prevalence of COVID-19 amongst hospitalized infants varies with ranges of group transmission (2021, June 30)
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